Assessment of Microvessel Density (Angiogenesis) and its Correlation with Hormonal Status of Carcinoma Breast

Background: Carcinoma Breast is the commonnest malignancy in women. Evaluation of microvessel density (MVD) provides additional information regarding the biological profile of the tumor. Aim: To detect the intratumoral MVD microscopically and tumor angiogenesis using vascular endothelial growth factor (VEGF) and ER, PR, HER2/neu status and to correlate MVD and VEGF with ER, PR, HER2/neu status. Materials and Methods: 50 cases of INVASIVE DUCTAL CARCINOMA-NOS type of breast cancers reported during the year 2014 were selected and Hematoxylin & Eosin slides were reviewed. IHC was done for VEGF, ER, PR, HER2/neu and the results were documented. Results: The Majority (50%) of cases showed ER/PR negativity while HER2/neu was positive in 34.8% of cases. Mean MVD was 33.19. However there was no significant correlation between VEGF expression and hormone receptor status in this study. Conclusion: The assessment of MVD, VEGF and hormone receptor status have applications in the evaluation of prognosis and as a therapeutic target. However study involving large sample size and computerized image analysis will help in identifying the exact association of MVD and VEGF with other prognostic factors.